| Day | Date | Opponent | Time | TV | Result |
| Saturday | Aug. 4 | Dallas | 6 p.m. | KICU | 21-14 |
| Saturday | Aug. 11 | at Arizona | 8 p.m. | KICU | 10-7 |
| Sunday | Aug. 19 | at San Francisco | 4 p.m. | KTVU | 17-20 |
| Monday | Aug. 27 | Dallas* | 5 p.m. | ABC | 6-21 |
| Friday | Aug. 31 | Green Bay | 6 p.m. | KICU | 24-13 |
| Day | Date | Opponent | Time | TV | Result |
| Sunday | Sept. 9 | at Kansas City | 10 a.m. | CBS | 27-24 |
| Sunday | Sept. 16 | N.Y. Jets | 1:15 p.m. | CBS | PPD |
| Sunday | Sept. 23 | at Miami | 10 a.m. | CBS | 15-18 |
| Sunday | Sept. 30 | Seattle | 1:15 p.m. | CBS | 38-14 |
| Sunday | Oct. 7 | Dallas | 1:15 p.m. | FOX | 28-21 |
| Sunday | Oct. 14 | at Indianapolis | 5:30 p.m. | ESPN | 23-18 |
| Sunday | Oct. 21 | Bye | |||
| Sunday | Oct. 28 | at Philadelphia | 1:15 p.m. | CBS | 20-10 |
| Monday | Nov. 5 | Denver | 6 p.m. | ABC | 38-28 |
| Sunday | Nov. 11 | at Seattle | 5:30 p.m. | ESPN | 27-34 |
| Sunday | Nov. 18 | San Diego | 1:05 p.m. | CBS | 34-24 |
| Sunday | Nov. 25 | at N.Y. Giants | 1:15 p.m. | CBS | 28-10 |
| Sunday | Dec. 2 | Arizona | 1:15 p.m. | FOX | 31-34 |
| Sunday | Dec. 9 | Kansas City | 1:15 p.m. | CBS | 28-26 |
| Saturday | Dec. 15 | at San Diego | 2 p.m. | CBS | 13-6 |
| Saturday | Dec. 22 | Tennessee | 6 p.m. | ABC | 10-13 |
| Sunday | Dec. 30 | at Denver | 1:15 p.m. | CBS | 17-23 |
| Sunday | Jan. 6. | N.Y. Jets | 1:15 p.m. | CBS | 22-24 |
| Day | Date | Opponent | Time | TV | Result |
| Saturday | Jan. 12 | N.Y. Jets | 5 p.m. | ABC | 38-24 |
| Saturday | Jan. 19 | at New England | 5 p.m. | CBS | 13-16 |
Wild Card round
